Wise2 is a package focused on comparisons of biopolymers, commonly DNA and
protein sequence. Wise2's particular forte is the comparison of DNA sequence
at the level of its protein translation. This comparison allows the
simultaneous prediction of say gene structure with homology based alignment.

The Wise2 package was principally written by Ewan Birney, who wrote the main
genewise and estwise programs. The protein comparison database search program
was written by Richard Copley using the underlying Wise2 libraries.
Wise2 also uses code from Sean Eddy for reading HMMs and
for Extreme value distribution fitting.